Embodiments relate generally to computer network architectures for machine learning, and more specifically, to computer network architectures in the context of program rules, using combinations of defined patient clinical episode metrics and other clinical metrics, thus enabling superior performance of computer hardware. Aspects of embodiments herein are specific to patient clinical episode definitions, and are applied to the specific outcomes of highest concern to each episode type. Furthermore, aspects of embodiments herein produce more accurate and reliable predictions of possible patient outcomes and metrics.