A system, device, and method for visualizing vascular structures is disclosed. According to some implementations, in order to provide further improved digital subtraction angiography, a device for visualizing vascular structures is provided that includes a data provision processor, an image processor, and an output. The data provision processor is configured to provide a first sequence of non-contrast X-ray images of a region of interest of a patient for use as raw X-ray mask images. The data provision processor is also configured to provide a second sequence of contrast X-ray images of the region of interest of a patient for use as raw X-ray live-images. The image processor is configured to perform a first spatial subtraction for the first sequence of non-contrast X-ray images resulting in a first sequence of spatial-subtracted mask images. The image processor is also configured to perform a second spatial subtraction for the second sequence of contrast X-ray images resulting in a second sequence of spatial-subtracted X-ray live-images. The image processor is further configured to perform a temporal subtraction by subtracting the spatial-subtracted mask images from the spatial-subtracted X-ray live-images resulting in a sequence of spatial-temporal subtracted X-ray live-images. The output is configured to output the sequence of spatial-temporal subtracted X-ray live-images.