A hemostasis pressure device is disclosed. In one embodiment, the hemostasis pressure device includes a reusable component and a disposable cuff. The disposable cuff includes a pre-inflated pad configured to be placed at an access site on a patient. A knob secured to the reusable component is configured to control the pressure applied to the pre-inflated pad, providing incremental, fine-tuned control of pressure applied to the access site to achieve patent hemostasis.