The present invention relates to an assembly-type cartridge block enabling various types of cartridges, and a hollow-fiber membrane module comprising the same. The assembly-type cartridge block of an embodiment of the present invention comprises: a body part having a plurality of hollow-fiber membranes therein and having mesh parts formed respectively at the upper and lower parts thereof; and a fastening part formed on a side surface of the body part and configured to be fastened to an adjacent assembly-type cartridge block. Further, the hollow-fiber membrane module of an embodiment of the present invention comprises: a housing unit including a first fluid inlet, a first fluid outlet, a second fluid inlet, and a second fluid outlet; and a cartridge unit installed inside the housing unit and formed by fastening a plurality of assembly-type cartridge blocks, each of the assemble type cartridge blocks having a plurality of hollow-fiber membranes therein.