A novel power slide with a motor directly connected to a lead screw includes a left slide and a right slide each including a top rail, a bottom rail, a power motor, a lead screw, a threaded assembly and a retainer ring. A first slot and a second slot are formed in two ends of the top rail, respectively. The power motor is fixed to a lower surface of the top rail through a motor bracket. The lead screw has an end connected to the power motor and another end rotatably fixed to the lower surface of the top rail. A bottom portion of the threaded assembly is fixedly connected to an upper surface of the bottom rail, and the lead screw horizontally penetrates through the threaded assembly and is in threaded fit with the threaded assembly. The retainer ring is located in the first slot, and a gap is formed between the retainer ring and the first slot.