Invention Grant
- Patent Title: Curcumin analogues as zinc chelators and their uses
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Application No.: US16885800Application Date: 2020-05-28
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Publication No.: US11608309B2Publication Date: 2023-03-21
- Inventor: Francis Johnson , Lorne Golub
- Applicant: Francis Johnson , Lorne Golub
- Applicant Address: US NY Setauket; US NY Smithtown
- Assignee: Francis Johnson,Lorne Golub
- Current Assignee: Francis Johnson,Lorne Golub
- Current Assignee Address: US NY Setauket; US NY Smithtown
- Agent Gary J. Gershik
- Main IPC: C07C69/738
- IPC: C07C69/738 ; C07C49/255 ; C07C225/22 ; C07C235/78 ; C07C237/20 ; C07D213/50 ; C07C235/80 ; C12N9/64

Abstract:
This invention provides a compound having the structure wherein α, β, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFκ-B activation in a population of cells.
Public/Granted literature
- US20210053905A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES Public/Granted day:2021-02-25
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