Invention Grant
- Patent Title: 5-HT2C receptor agonists and compositions and methods of use
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Application No.: US17073458Application Date: 2020-10-19
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Publication No.: US11608339B2Publication Date: 2023-03-21
- Inventor: Graeme Semple , Albert S. Ren , Thomas O. Schrader , Michelle Kasem , Xiuwen Zhu
- Applicant: Arena Pharmaceuticals, Inc.
- Applicant Address: US CA San Diego
- Assignee: Arena Pharmaceuticals, Inc.
- Current Assignee: Arena Pharmaceuticals, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Fish & Richardson P.C.
- Main IPC: C07D471/14
- IPC: C07D471/14 ; A61P3/00

Abstract:
The present invention relates to compounds of Formula A and pharmaceutical compositions thereof that modulate the activity of the 5-HT2C receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a 5-HT2C receptor-mediated disorder, such as, weight management, inducing satiety, and decreasing food intake, and for preventing and treating obesity, antipsychotic-induced weight gain, type 2 diabetes, Prader-Willi syndrome, tobacco/nicotine dependence, drug addiction, alcohol addiction and the like, obsessive-compulsive spectrum disorders and impulse control disorders (including nail-biting and onychophagia), sleep disorders, urinary incontinence, psychiatric disorders (including schizophrenia, anorexia nervosa, and bulimia nervosa), Alzheimer disease, sexual dysfunction, erectile dysfunction, epilepsy, movement disorders (including parkinsonism and antipsychotic-induced movement disorder), hypertension, dyslipidemia, nonalcoholic fatty liver disease, obesity-related renal disease, and sleep apnea. Also provided are compositions comprising a compound herein, optionally in combination with a supplemental agent.
Public/Granted literature
- US20210214355A1 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE Public/Granted day:2021-07-15
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