Invention Grant
- Patent Title: Method of preparing composition containing factor VIII (FVIII) and von Willebrand factor (vWF) with controlled content of von Willebrand factor (vWF)
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Application No.: US16758386Application Date: 2018-10-26
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Publication No.: US11608358B2Publication Date: 2023-03-21
- Inventor: Jee Won Ahn , Kwan Young Ko , Jeong Hye Yoon , Seung-Ho Baek , Min Jung Kim , Geun Hye Yeo , Jung-Ae Lim , Soo-kwang Kim
- Applicant: GREEN CROSS HOLDINGS CORPORATION
- Applicant Address: KR Gyeonggi-do
- Assignee: GREEN CROSS HOLDINGS CORPORATION
- Current Assignee: GREEN CROSS HOLDINGS CORPORATION
- Current Assignee Address: KR Gyeonggi-do
- Agency: Hultqvist, PLLC
- Agent Steven J. Hultquist
- Priority: KR10-2017-0141444 20171027
- International Application: PCT/KR2018/012820 WO 20181026
- International Announcement: WO2019/083319 WO 20190502
- Main IPC: C07K1/18
- IPC: C07K1/18 ; A61K38/37 ; B01D15/00 ; B01D15/36
Abstract:
Disclosed is a method for preparing a composition comprising factor VIII (FVIII) and von Willebrand factor (vWF), wherein the content of the von Willebrand factor (vWF) can be controlled by mixing the factor VIII (FVIII) with the von Willebrand factor (vWF) at an appropriate ratio after separately purifying the factor VIII (FVIII) and the von Willebrand factor (vWF) from plasma in a single process. The method can prepare and purify a composition comprising factor VIII (FVIII) and a varying content of von Willebrand factor (vWF) without increasing the amount of impurities other than the von Willebrand factor (vWF) compared to a method of purifying factor VIII (FVIII) separately, without significantly increasing the processing time (within 3 hours) compared to a method of purifying factor VIII (FVIII), and without changing the yield of factor VIII (FVIII).
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