Invention Grant
- Patent Title: Construction of chimeric antigen receptor targeting CD20 antigen and activity identification of engineered T cells thereof
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Application No.: US17750855Application Date: 2022-05-23
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Publication No.: US11608369B2Publication Date: 2023-03-21
- Inventor: Yihong Yao , Jiaqi Huang , Shigui Zhu , Wei Zhu , Xin Yao , Zhiyuan Li , Li Zhang , Lin Zhu , Anyun Ma , Yutian Wei , Yanfeng Li , Qingxia Wang , Jiaping He
- Applicant: Cellular Biomedicine Group, Inc.
- Applicant Address: US MD Rockville
- Assignee: Cellular Biomedicine Group, Inc.
- Current Assignee: Cellular Biomedicine Group, Inc.
- Current Assignee Address: US MD Rockville
- Agency: Leason Ellis LLP
- Priority: CN201710069569.7 20170208
- Main IPC: C07K14/725
- IPC: C07K14/725 ; A61P35/00 ; A61K35/17 ; C07K14/705 ; C07K16/28 ; C12N7/00 ; C12N15/86 ; C07K19/00 ; C12N5/10 ; C12N15/62 ; A61P35/02 ; A61K9/00 ; A61K38/00 ; A61K39/00
Abstract:
Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.
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