A choke can include a variable flow restrictor, external ports in communication with a flow passage respectively upstream and downstream of the flow restrictor, and sensor(s) in communication with the external ports. A method can include flowing a well fluid through a flow passage in a body of a choke including a variable flow restrictor, measuring a pressure differential between external ports in communication with respective upstream and downstream sides of the flow restrictor, and operating the flow restrictor, thereby varying a restriction to the flow through the flow passage, in response to the measured pressure differential. A well system can include a well fluid pump, a flow choke including a variable flow restrictor operable by an actuator that includes a displaceable stem and a stem seal that isolates the actuator from the well fluid in the flow choke, and a control system that operates the actuator.