According to one embodiment, a data processing system performs a secure boot using a security module (e.g., a trusted platform module (TPM)) of a host system. The system verifies that an operating system (OS) and one or more drivers including an accelerator driver associated with a data processing (DP) accelerator is provided by a trusted source. The system launches the accelerator driver within the OS. The system generates a trusted execution environment (TEE) associated with one or more processors of the host system. The system launches an application and a runtime library within the TEE, where the application communicates with the DP accelerator via the runtime library and the accelerator driver.