A medication adherence system with a pill container with 2D barcodes printed along one or more compartment stores medication to be taken. A user scans the 2D barcode using a first electronic device with a mobile app installed and the user confirms the correct medication for the appropriate day and the system synchronizes scanning and scheduling data to an Internet cloud service. Separately, proxy users and caregivers can use a second electronic device to retrieve data from the cloud and manage a patient's medication scheduling and the devices are in data communication through the mobile app and associated cloud service. Proxy users can seamlessly monitor and manage medication adherence of semi-independent persons using the described system.