A multiple perforation plate for a separator of a fuel cell is provided. The multiple perforation plate is disposed between the separator having a flat plate shape and a gas diffusion layer to form flow paths for a reaction gas, and the multiple perforation plate includes a porous hole region having an uneven shape repeatedly formed therein and provided with a plurality of flow path holes configured to allow the reaction gas to flow in a turbulent way, and a channel region forming a flow path configured to allow the reaction gas to flow along a flow direction of the reaction gas in a straight way, wherein the porous hole region and the channel region are alternately disposed and integrally formed.