A medical skin wrinkle reduction device using an RRSS laser irradiation method is proposed to reduce skin wrinkles and minimize tissue damage. The device includes: a main body having a mounting groove provided in an upper portion thereof, a tablet computer being attached to and detached from the mounting groove, and comprising signal transmission and reception parts exchanging signals with the tablet computer, and a microcomputer controlling an output of a laser beam; a handpiece comprising: a laser oscillation part generating the laser beam; an optical part emitting the laser beam as parallel light; a laser scanner controlling an irradiation position of the laser beam transmitted from the optical part; a laser pattern part having movement coordinate values set therein such that moving direction of the laser beam has a regular pattern; a tablet computer having functions of inputting data in a touch screen method and displaying a screen.