Invention Grant
- Patent Title: Next-generation biomarkers to detect sun damage and predict skin cancer risk
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Application No.: US16072825Application Date: 2017-03-16
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Publication No.: US11613784B2Publication Date: 2023-03-28
- Inventor: Liang Liu , Yao Shen
- Applicant: The Trustees of Columbia University in the City of New York
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Bryan Cave Leighton Paisner, LLP
- International Application: PCT/US2017/022848 WO 20170316
- International Announcement: WO2017/165199 WO 20170928
- Main IPC: C12Q1/6886
- IPC: C12Q1/6886
Abstract:
The present invention provides methods of detecting ultraviolet radiation (UVR)-induced skin damage in a subject. The method includes the steps of: a) obtaining a skin sample from the subject; b) analyzing expression levels in the skin sample of UVR-induced differentially expressed genes (DEGs) listed in Table 8 or a subset thereof; and c) comparing the expression levels of the UVR-induced DEGs to a control skin sample; wherein, when the expression levels of the UVR-induced DEGs in the skin sample is above or below the level of each of the UVR-induced DEGs in the control sample, the subject is identified as likely being afflicted with UVR-induced skin damage. Also provided are methods for measuring the effectiveness of a test agent in reducing ultraviolet radiation (UVR)-induced damage.
Public/Granted literature
- US20210054462A1 NEXT-GENERATION BIOMARKERS TO DETECT SUN DAMAGE AND PREDICT SKIN CANCER RISK Public/Granted day:2021-02-25
Information query
IPC分类:
