Invention Grant
- Patent Title: Clonal haematopoiesis
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Application No.: US16858085Application Date: 2020-04-24
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Publication No.: US11613786B2Publication Date: 2023-03-28
- Inventor: Steven A. McCarroll , Giulio Genovese
- Applicant: President and Fellows of Harvard College , The Broad Institute, Inc.
- Applicant Address: US MA Cambridge; US MA Cambridge
- Assignee: President and Fellows of Harvard College,The Broad Institute, Inc.
- Current Assignee: President and Fellows of Harvard College,The Broad Institute, Inc.
- Current Assignee Address: US MA Cambridge; US MA Cambridge
- Agency: Foley Hoag LLP
- Agent Brendan T. Jones
- Main IPC: C12Q1/6886
- IPC: C12Q1/6886 ; C12Q1/6883
Abstract:
The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.
Public/Granted literature
- US20210123105A1 CLONAL HAEMATOPOIESIS Public/Granted day:2021-04-29
Information query
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