A pressure calibration method, applicable to a touch panel which sequentially comprises a first electrode layer, an elastic dielectric layer and a second electrode layer, the first electrode layer includes multiple first electrodes in parallel to a first axis, the second electrode layer includes multiple second electrodes in parallel to a second axis, the pressure calibration method comprising: retrieving a depression event according to mutual capacitance sensing between the first electrodes and the second electrodes; finding a corresponding calibration area according to coordinate of the depression event; and calculating a calibrated pressure value according to a pressure sensing value of the depression event and a pressure calibration function of the corresponding calibration area.