Methods, apparatus, systems, and articles of manufacture are disclosed herein to enable data aggregation and pattern adaptation in hardware acceleration subsystems. In some examples, a hardware acceleration subsystem includes a first scheduler, a first hardware accelerator coupled to the first scheduler to process at least a first data element and a second data element, and a first load store engine coupled to the first hardware accelerator, the first load store engine configured to communicate with the first scheduler at a superblock level by sending a done signal to the first scheduler in response to determining that a block count is equal to a first BPR value and aggregate the first data element and the second data element based on the first BPR value to generate a first aggregated data element.