Systems, computer-implemented methods, and computer program products that can facilitate quantum circuit topology selection based on frequency collisions between qubits, are described. According to an embodiment, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise a simulation component that simulates operation of qubits in a subgraph topology of a graph representing a topology of a quantum circuit to determine a quantity of frequency collisions between the qubits. The computer executable components can further comprise a selection component that selects a quantum circuit topology based on the quantity of frequency collisions between the qubits.