A method for automatic selection of display settings for a medical image is provided. The method includes receiving a medical image, mapping the medical image to an appearance classification cell of an appearance classification matrix using a trained deep neural network, selecting a first WW and a first WC for the medical image based on the appearance classification and a target appearance classification, adjusting the first WW and the first WC based on user preferences to produce a second WW and a second WC, and displaying the medical image with the second WW and the second WC via a display device.