Invention Grant
- Patent Title: Pharmaceutical formulation for administering paracetamol by buccal/gingival route
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Application No.: US16489378Application Date: 2018-02-28
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Publication No.: US11617730B2Publication Date: 2023-04-04
- Inventor: Eric Goupil
- Applicant: Unither Pharmaceuticals
- Applicant Address: FR Amiens
- Assignee: Unither Pharmaceuticals
- Current Assignee: Unither Pharmaceuticals
- Current Assignee Address: FR Amiens
- Agency: Lerner, David, Littenberg, Krumholz & Mentlik, LLP
- Priority: FR1751652 20170228
- International Application: PCT/EP2018/054949 WO 20180228
- International Announcement: WO2018/158324 WO 20180907
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K31/167 ; A61K47/02 ; A61K47/10

Abstract:
The present invention concerns a pharmaceutical formulation for administering paracetamol by buccal/gingival route consisting of a hydroalcoholic solution comprising dissolved paracetamol, characterised in that: #the mass of paracetamol is between 95 mg and 190 mg, #the volume of said hydroalcoholic solution is between 1.0 ml and 2.0 ml, #the degree of alcohol of said hydroalcoholic solution is between 48.5° and 52.5°, and #the concentration of paracetamol in said hydroalcoholic solution is between 85 mg/ml and 110 mg/ml. The present invention also concerns said pharmaceutical formulation for the use of same for accelerating the speed at which paracetamol passes through the blood-brain barrier, and the use thereof as a drug, in particular for the symptomatic treatment of pain or fever.
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