Invention Grant
- Patent Title: Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
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Application No.: US16550763Application Date: 2019-08-26
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Publication No.: US11617750B2Publication Date: 2023-04-04
- Inventor: John H. van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
- Applicant: Acetylon Pharmaceuticals, Inc.
- Applicant Address: US MA Boston
- Assignee: Acetylon Pharmaceuticals, Inc.
- Current Assignee: Acetylon Pharmaceuticals, Inc.
- Current Assignee Address: US MA Boston
- Agency: Lathrop GPM LLP
- Agent Brian C. Trinque; Nicole Sassu
- Main IPC: C07D235/30
- IPC: C07D235/30 ; C07D239/42 ; C07D241/20 ; C07C259/06 ; C07D213/74 ; C07D277/82 ; C07D209/48 ; C07D401/12 ; C07D417/06 ; C07D213/81 ; C07D401/06 ; C07D403/04 ; C07D213/30 ; C07D277/24 ; C07D209/46 ; C07D413/04 ; C07D401/04 ; C07D263/58 ; C07C237/36 ; A61K31/505 ; A61K31/164 ; A61K31/337 ; A61K45/06
Abstract:
The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
Public/Granted literature
- US20200030325A1 Reverse Amide Compounds As Protein Deacetylase Inhibitors And Methods Of Use Thereof Public/Granted day:2020-01-30
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