Disclosed are a flue gas purification and waste heat utilization system and method. The system comprises a flue gas exhaust unit, a primary waste heat utilization unit, a primary flue gas purification unit, a secondary waste heat utilization unit and a secondary flue gas purification unit that are sequentially connected in a flue gas flow direction, wherein the primary flue gas purification unit is configured for removing NOx, large particles and CO in the flue gas, the secondary flue gas purification unit is configured for removing NOx and dioxin in the flue gas, an ammonia-spraying device is externally connected between the flue gas exhaust unit and the primary waste heat utilization unit, and the ammonia-spraying device is configured for injecting ammonia gas into the flue gas exhausted from the flue gas exhaust unit.