Invention Grant
- Patent Title: Covalently fused viral coat proteins for the display of target molecules
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Application No.: US17361835Application Date: 2021-06-29
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Publication No.: US11618771B2Publication Date: 2023-04-04
- Inventor: Stephen Tottey , Konstantin Musiychuk
- Applicant: Fraunhofer USA Inc.
- Applicant Address: US DE Newark
- Assignee: Fraunhofer USA Inc.
- Current Assignee: Fraunhofer USA Inc.
- Current Assignee Address: US DE Newark
- Agency: RatnerPrestia
- Main IPC: A61K39/12
- IPC: A61K39/12 ; A61K39/00 ; C07K14/005 ; C07K14/415 ; C12N7/01 ; A61K39/015 ; C12N15/11

Abstract:
A fusion protein comprising a target protein, a first recombinant viral coat protein, a second recombinant viral coat protein and a first linkage peptide is provided. The target protein is at N-terminus of the first recombinant viral coat protein. The first recombinant viral coat protein is linked to N-terminus of the first linkage peptide. The second recombinant viral coat protein is linked to C-terminus of the first linkage peptide. The first and second recombinant viral coat proteins are derived from the coat protein (CP) of alfalfa mosaic virus (AIMV). The fusion protein may further comprise a second linkage peptide between the target protein and the first recombinant viral coat protein. The fusion protein may form a virus like particle (VLP). The target protein may be displayed on the surface of the VLP. Also provided are methods for producing the fusion protein and the VLP as well as the uses of the fusion protein and/or the VLP.
Public/Granted literature
- US20210324015A1 COVALENTLY FUSED VIRAL COAT PROTEINS FOR THE DISPLAY OF TARGET MOLECULES Public/Granted day:2021-10-21
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