Invention Grant
- Patent Title: Tumor-selective E1A and E1B mutants
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Application No.: US17100671Application Date: 2020-11-20
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Publication No.: US11618888B2Publication Date: 2023-04-04
- Inventor: Tony Reid , Farah Hedjran , Shantanu Kumar
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Main IPC: C12N15/86
- IPC: C12N15/86 ; C12N15/861 ; C12N7/00 ; A61K35/761 ; C07K14/005 ; A61K48/00
Abstract:
Modified E1a regulatory sequences are provided, wherein at least one Pea3 binding site, or a functional portion thereof, is deleted. Also provided are modified E1a sequences that selectively express particular isoforms. Also provided is an E1b-19K clone insertion site. These modified sequences can be used individually, or in combination with one another, to provide tumor-selective expression of proteins.
Public/Granted literature
- US20210171917A1 TUMOR-SELECTIVE E1A AND E1B MUTANTS Public/Granted day:2021-06-10
Information query
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