An apparatus for an architectural opening may include a plurality of panels. At least one of the plurality of panels may include a frame including a plurality of first frame members and a plurality of second frame members sealed together at respective interfaces to define at least one opening. The interfaces may be defined by ends of the first frame members positioned at least partially within respective apertures defined in the second frame members. Each frame member may include an internal cavity, with the apertures fluidically connecting the internal cavities of the frame members. An inset panel may be secured within the at least one opening. One or more hinges may pivotably connect a first panel of the plurality of panels to a second panel of the plurality of panels. The apparatus may be a garage door, an entry door, a window, or a storefront.