Invention Grant
- Patent Title: Process for ultra-sensitive quantification of target analytes in complex biological systems
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Application No.: US14949385Application Date: 2015-11-23
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Publication No.: US11619635B2Publication Date: 2023-04-04
- Inventor: Tujin Shi , Weijun Qian , Thomas L. Fillmore , Xuefei Sun , Richard D. Smith
- Applicant: BATTELLE MEMORIAL INSTITUTE
- Applicant Address: US WA Richland
- Assignee: BATTELLE MEMORIAL INSTITUTE
- Current Assignee: BATTELLE MEMORIAL INSTITUTE
- Current Assignee Address: US WA Richland
- Agency: Wells St. John P.S.
- Main IPC: G01N33/68
- IPC: G01N33/68 ; G01N30/86 ; G01N33/50 ; G01N30/72 ; G01N30/88

Abstract:
Antibody-free processes are disclosed that provide accurate quantification of a wide variety of low-abundance target analytes in complex samples. The processes can employ high-pressure, high-resolution chromatographic separations for analyte enrichment. Intelligent selection of target fractions may be performed via on-line Selected Reaction Monitoring (SRM) or off-line rapid screening of internal standards. Quantification may be performed on individual or multiplexed fractions. Applications include analyses of, e.g., very low abundance proteins or candidate biomarkers in plasma, cell, or tissue samples without the need for affinity-specific reagents.
Public/Granted literature
- US20160238614A1 PROCESS FOR ULTRA-SENSITIVE QUANTIFICATION OF TARGET ANALYTES IN COMPLEX BIOLOGICAL SYSTEMS Public/Granted day:2016-08-18
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