A cooling control system and method for a motor vehicle comprising: a server unit and N client units, wherein N is greater than or equal to 1, the server unit being in data connection with the N client units via a wireless network, the N client units configured to be arranged on N motor vehicles respectively, each client unit configured to perform real-time collection and storage of calculation input data on the corresponding motor vehicle for evaluating a temperature of a unit requiring cooling on the motor vehicle, perform real-time collection and storage of temperature data of the unit requiring cooling, predict, using the collected calculation input data, temperature data at a future time of the unit requiring cooling based on a predictive mathematical model determined by the server unit (200), and enable the selective cooling in advance of the unit requiring cooling based on the predicted temperature data.