Systems and methods for data aggregation and processing are provided in manner that is decentralized and preserves privacy. A data aggregation and computation system may include an interface, a controller, and one or more clusters of computation nodes. The interface may receive an inquiry from a requesting entity for computing information regarding an individual based on pieces of information held by a plurality of entities. The controller may communicate an identifier for the individual to a processor system associated with each of the entities based on the inquiry. The clusters of computation nodes may each receive encrypted data fragments from each of the processor systems, the data fragments comprising unrecognizable fragments that no individual processor system can re-assemble to recover the information, perform secure, multi-party computations based on the data fragments, and generate a result based on the secure, multi-party computations for the individual.