Drone-based inventory management method and systems. One embodiment provides a drone-based inventory management system including one or more unmanned aerial vehicles (UAVs), and a central management system having an electronic processor, and a transceiver configured to communicate with the one or more UAVs. The electronic processor is configured to determine a discrepancy in inventory and select a UAV for verification. The electronic processor is also configured to determine whether weather permits UAV operation and operate the UAV in a pre-determined route when the weather permits UAV operation. The electronic processor is further configured to capture images using the UAV and determine new inventory based on captured images. The electronic processor is also configured to update inventory based on the new inventory.