Adaptive packet scheduling for interference mitigation is disclosed. Current spectral information can be compared to historical spectral information to determine a likelihood of a future interference event. Based on the furfure interference event, a data frame can be adapted to mitigate the effect of the future interference event on wireless communication. The interference event can be related to an unintentional interference source that can have distinct interference characteristics distinguishing it from an intentional interference source. Comparison can be facilitated by a data store storing historical interference information related to one or more historical interference events.