Invention Grant
- Patent Title: Prodruggable antibodies, prodrugs thereof, and methods of use and making
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Application No.: US16103654Application Date: 2018-08-14
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Publication No.: US11623965B2Publication Date: 2023-04-11
- Inventor: Stanley R. Krystek, Jr. , Yong Zhang , Gregory D. Vite , Arvind Rajpal , Chetana Rao-Naik , Paul E. Morin , Mohan Srinivasan , Zheng Lin , Virginie Lafont , Alla Pritsker
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Bing Hai
- Main IPC: C07K16/46
- IPC: C07K16/46 ; A61K39/395 ; A61K47/60 ; A61K47/65 ; C07K16/28 ; A61P29/00 ; A61P35/00
Abstract:
A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.
Public/Granted literature
- US20190055321A1 PRODRUGGABLE ANTIBODIES, PRODRUGS THEREOF, AND METHODS OF USE AND MAKING Public/Granted day:2019-02-21
Information query
