- Patent Title: Enrichment of mutated cell free nucleic acids for cancer detection
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Application No.: US16309427Application Date: 2017-06-13
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Publication No.: US11624064B2Publication Date: 2023-04-11
- Inventor: Gordon Cann , Alex Aravanis , Arash Jamshidi , Rick Klausner , Richard Rava
- Applicant: GRAIL, LLC
- Applicant Address: US CA Menlo Park
- Assignee: GRAIL, LLC
- Current Assignee: GRAIL, LLC
- Current Assignee Address: US CA Menlo Park
- Agency: Haynes and Boone, LLP
- International Application: PCT/US2017/037223 WO 20170613
- International Announcement: WO2017/218512 WO 20171221
- Main IPC: C12N15/10
- IPC: C12N15/10 ; C12Q1/6806 ; C12Q1/6827 ; C12Q1/6869 ; C12Q1/6809 ; C12N9/22
Abstract:
Provided herein are methods of enriching mutated cell free nucleic acids for detection and diagnosis of cancer. Also provided are methods using a CRISPR-Cas system to target and deplete unwanted more abundant cell free nucleic acid sequences thereby enriching for less abundant sequences.
Public/Granted literature
- US20190161752A1 ENRICHMENT OF MUTATED CELL FREE NUCLEIC ACIDS FOR CANCER DETECTION Public/Granted day:2019-05-30
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