An automatic protocolling system and methods involving a processor operable by way of a set of executable instructions storable in relation to a nontransient memory device, the set of executable instructions configuring the processor to: receive information relating to an initial protocol comprising an initial ordering of a plurality of sequences, the information comprising data relating to an interaction extent value of at least one of an imaging system and a patient as a function of time corresponding to each sequence in the plurality of sequences, the data relating to a time-integrated effect of each sequence in the plurality of sequences; and dynamically determine an alternative protocol comprising an alternative ordering of the plurality of sequences based on the time-integrated effect, whereby an alternative protocol is provided.