The technology disclosed relates to inter-node execution of configuration files on reconfigurable processors using smart network interface controller (SmartNIC) buffers. In particular, the technology disclosed relates to a runtime logic that is configured to execute configuration files that define applications and process application data for applications using a first reconfigurable processor on a first node, and a second host processor on a second node. The execution includes streaming configuration data in the configuration files and the application data between the first reconfigurable processor and the second host processor using one or more SmartNIC buffers.