Systems and methods provide for optimizing utilization of an Address Translation Cache (ATC). A network interface controller (NIC) can write information reserving one or more cache lines in a first level of the ATC to a second level of the ATC. The NIC can receive a request for a direct memory access (DMA) to an untranslated address in memory of a host computing system. The NIC can determine that the untranslated address is not cached in the first level of the ATC. The NIC can identify a selected cache line in the first level of the ATC to evict using the request and the second level of the ATC. The NIC can receive a translated address for the untranslated address. The NIC can cache the untranslated address in the selected cache line. The NIC can perform the DMA using the translated address.