A ventilation management system stores an initial configuration profile including a set of operating parameters for operating one or more respective ventilation devices. The system receives first ventilator data from a first ventilation device at a first location, and second ventilator data from a second ventilation device at a second location, the first and second ventilation devices being configured to operate based on the initial configuration profile, wherein the received first ventilator data comprises one or more current operating parameters of the first ventilation device, or physiological data obtained from a patient associated with the first ventilation device. The system modifies the initial configuration profile for use by the first ventilation device based on the received first ventilation data and provides the modified configuration profile to the first ventilation device. The modified configuration profile is implemented by the first ventilation device when approved by a clinician or the patient.