![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza](/docs/US/2023-04-18/US11629149B2/abs.jpg.600x600.jpg)
- Patent Title: 10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza
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Application No.: US16975784Application Date: 2019-02-26
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Publication No.: US11629149B2Publication Date: 2023-04-18
- Inventor: Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: McNeill Baur PLLC
- International Application: PCT/IB2019/051549 WO 20190226
- International Announcement: WO2019/166950 WO 20190906
- Main IPC: C07D487/14
- IPC: C07D487/14 ; C07D498/14
![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza](/abs-image/US/2023/04/18/US11629149B2/abs.jpg.150x150.jpg)
Abstract:
The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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