Invention Grant
- Patent Title: Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity
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Application No.: US17050663Application Date: 2019-04-25
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Publication No.: US11629154B2Publication Date: 2023-04-18
- Inventor: Genta Tadano , Shinji Suzuki , Ken-ichi Kusakabe
- Applicant: SHIONOGI & CO., LTD.
- Applicant Address: JP Osaka
- Assignee: SHIONOGI & CO., LTD.
- Current Assignee: SHIONOGI & CO., LTD.
- Current Assignee Address: JP Osaka
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: JPJP2018-086206 20180427
- International Application: PCT/JP2019/017619 WO 20190425
- International Announcement: WO2019/208693 WO 20191031
- Main IPC: C07D498/04
- IPC: C07D498/04 ; A61P25/28 ; A61K9/00 ; A61K9/20 ; A61K9/48

Abstract:
The present invention provides a compound which has an effect of inhibiting amyloid ßproduction, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ßproteins.
A compound of Formula (I) wherein R3 is each independently alkyl optionally substituted with halogen, cyano, alkyloxy, haloalkyloxy or non-aromatic carbocyclyl, or the like; t is integer from 0 to 3; R5 is a hydrogen atom or halogen; R6 is selected from the group consisting of a hydrogen atom, halogen, and substituted or unsubstituted alkyl; ring B is a substituted or unsubstituted pyrazine or the like; or a pharmaceutically acceptable salt thereof.
A compound of Formula (I) wherein R3 is each independently alkyl optionally substituted with halogen, cyano, alkyloxy, haloalkyloxy or non-aromatic carbocyclyl, or the like; t is integer from 0 to 3; R5 is a hydrogen atom or halogen; R6 is selected from the group consisting of a hydrogen atom, halogen, and substituted or unsubstituted alkyl; ring B is a substituted or unsubstituted pyrazine or the like; or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20210238194A1 TETRAHYDROPYRANOOXAZINE DERIVATIVES HAVING SELECTIVE BACE1 INHIBITORY ACTIVITY Public/Granted day:2021-08-05
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