Invention Grant
- Patent Title: Methods of isolating T cells and T cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood
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Application No.: US16710287Application Date: 2019-12-11
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Publication No.: US11629334B2Publication Date: 2023-04-18
- Inventor: Alena Gros , Steven A. Rosenberg
- Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America,as represented by the Secretary,Department of Health and Human Services
- Current Assignee: The United States of America,as represented by the Secretary,Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Leydig, Voit & Mayer
- Main IPC: C12Q1/06
- IPC: C12Q1/06 ; C12N5/0783 ; A61P35/00 ; A61K38/17 ; C12N15/63
Abstract:
Disclosed are methods of isolating T cells and TCRs having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Also disclosed are related methods of preparing a population of cells, populations of cells, TCRs, pharmaceutical compositions, and methods of treating or preventing cancer.
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