A multi-screen display control device is shown, which is linked to a host through a universal serial bus (USB) port to receive image data from the host, and uses a plurality of high-definition multimedia interface (HDMI) ports to output a plurality of HDMI sub-images to a plurality of screens. The multi-screen display control device has a USB hub that couples the USB port to a plurality of graphics processing units (GPUs), so that the GPUs generate the HDMI sub-images based on the image data transferred from the host via USB communication technology.