A computer-implemented method of generating an operation procedure for a simulation of a system, in particular a mechatronic system is disclosed. A source node has at least one source parameter (Ps) and a first simulation system with at least one first simulation node is determined, wherein the first simulation node includes at least one input parameter (Pi) and at least one output parameter (Pa). The first simulation node includes a simulation function for determining the output parameter (Pa) based on the input parameter (Pi) of the first node. When the input parameter (Pi) is available based on the source parameter (Ps), a global operation graph is built describing a link between the source node and the first simulation node for describing an operating procedure of the simulation of the system.