Selection of an evaluation index based upon statistical values of respective evaluation indices is disclosed. In one example, an information processing apparatus comprises an evaluation index unit that determines a plurality of evaluation indices on a basis of imaging data obtained by imaging a subject, wherein the evaluation indices are respectively based upon different wavelength component combinations of the imaging data. An evaluation value unit determines an evaluation value based on a statistical value of each of the evaluation indices, for each of the evaluation indices. A selection unit then determines a selected evaluation index from the evaluation indices on a basis of the evaluation values.