Systems and methods are provided for operating a pair of earbuds based whether the earbuds are being worn by the same user or different users. In this regard, one or more processors may determine, based on sensor signals from the pair of earbuds, whether the pair of earbuds are being worn by a same user or different users. Based on determining that the pair of earbuds are being worn by the same user, the pair of earbuds may be operated in a first mode so that one or more functions are controlled based on a first set of input settings. Based on determining that the pair of earbuds are being worn by different users, the pair of earbuds may be operated in a second mode so that the one or more functions of the pair of earbuds are controlled based on a second set of input settings.