A wireless network including user equipment (UE) and base stations is configured to perform position determination with low latency and high availability within the Time-Sensitive Networking (TSN) framework. For example, the UE may be integrated as a sensor in a motion control system or similar applications. The UE and base stations are synchronized with the TSN clock, and are configured to perform positioning measurements at a specific time point within the TSN framework. The time point, for example, may be a global sampling point, at which all sensor nodes in the TSN framework perform position measurements. A location server may be provided with the positioning measurements or a position estimate from the UE and provide the position estimate to an external client, such as a motion controller in a motion control system.