An example embodiment involves persistent storage defining a first configuration item representing an application deployed within a network, a second configuration item representing a software program that is deployable within the network, and a relationship between the first configuration item and the second configuration item. One or more processors may be configured to: (i) receive an indication that a change has been applied to the application or has been arranged to be applied to the application; (ii) identify the relationship between the first configuration item and the second configuration item; (iii) based on the relationship between the first configuration item and the second configuration item, determine that the change can affect operation of the software program; and (iv) in response to determining that the change can affect operation of the software program, provide a notification of the change to an agent associated with the software program.