Systems and methods for determining a disease state of image elements are disclosed herein. An example method may include providing quantitative and non-quantitative images, determining a correspondence map of the quantitative images to an atlas, and determining candidate elements of the quantitative images by comparing the elements of the quantitative images to atlas elements of the atlas. The example method may also include localizing the candidate elements in the non-quantitative images, classifying the candidate elements based on properties of the non-quantitative images, and determining a disease state of the candidate elements.