A method for derivation of a machine signature includes receiving sensor information from a primary sensor, where the primary sensor is positioned to receive information from a portion of an industrial operation, and receiving sensor information from one or more secondary sensors. The secondary sensors are arranged to provide additional information about the industrial operation indicative of current operating conditions of the industrial operation. The method includes using the sensor information from the secondary sensors and machine learning to determine if the portion of the industrial operation is operating in a normal condition and, in response to determining that the portion of the industrial operation is operating normally, using sensor information from the primary sensor during the normal operating condition to derive a primary sensor signature for the sensor information from the primary sensor.