A radial artery sheath assembly includes a cuff that is wearable around a patient's wrist and a receiver is integrated into the cuff. The cuff is inflatable to compress an incision in the patient's wrist to achieve homeostasis for stopping bleeding. A ring is removably attachable to the cuff and a radial sheath is extendable through the ring to retain the radial sheath in the incision in the user's wrist when the ring is attached to the cuff. The ring is inflatable for compressing the radial sheath in the ring to inhibit the radial sheath from being removed from the incision. A lock is coupled to the ring and the lock releasably engages the receiver in the cuff for attaching the ring to the cuff.