Invention Grant
- Patent Title: Vaccine for eliciting immune response comprising lipid formulations and RNA encoding multiple immunogens
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Application No.: US17848299Application Date: 2022-06-23
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Publication No.: US11638694B2Publication Date: 2023-05-02
- Inventor: Andrew Geall
- Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
- Applicant Address: BE Rixensart
- Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
- Current Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
- Current Assignee Address: BE Rixensart
- Agency: Knobbe Martens Olson & Bear LLP
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K9/127 ; A61K39/12 ; C12N15/86 ; A61K31/7088 ; A61K39/00 ; A61K39/39
Abstract:
Provided are vaccines for eliciting an immune response. The vaccines for eliciting an immune response comprise RNA encoding an immunogen, which is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially neutral surface charge at physiological pH and are effective for immunisation.
Public/Granted literature
- US20220347097A1 VACCINE FOR ELICITING IMMUNE RESPONSE COMPRISING LIPID FORMULATIONS AND RNA ENCODING MULTIPLE IMMUNOGENS Public/Granted day:2022-11-03
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